Calcium Phosphate ceramics are biocompatible and bone-bonding biomaterials. They are the natural solution for bone substitution, because of their resemblance with bone mineral composed of ~60wt % of calcium phosphate. They induce a biological response similar to the one generated during bone remodeling. Calcium phosphate biomaterials are resorbed by cells and by dissolution. The resorption products are calcium and phosphate ions that are naturally metabolized. Their unique bone bonding properties are related to their composition and surface properties governing ionic and molecular exchanges and their ability to support cell colonization.

Bone formation on Calcium Phosphate (CaP). Osteoblasts (yellow arrow) form new bone (NB) directly on Calcium Phosphate biomaterials, and multinucleated resorbing cells (yellow *) directly attached on the Calcium Phosphate biomaterial